Hormone-toxins to reduce possum fertility
Scientists in New Zealand are investigating whether a roundworm parasite could be used to deliver a hormone toxin to possums.
This story will focus on research by scientists at AgResearch, They are investigating the use of a hormone-toxin which destroys the cells that produce fertility hormones. The hormone that is used to deliver the toxin to these cells is called Gonadotrophin-Releasing Hormone (GnRH). The toxin, when delivered specifically to cells in the pituitary gland, destroys only those cells and makes possums sterile or less fertile than they would normally be. The toxin will not kill the possum.
Getting the biocontrol agent to the possums
One way of getting the hormone-toxin to the possum is to use bait. The problem with this method is that the bait needs to be re-distributed over and over. This is expensive.
Get information sheet: Delivering biocontrol agents to possums
A natural possum parasite
Another way of spreading the hormone-toxin amongst possums is to use a naturally occurring vector. A vector is a carrier organism.
In this case, the vector could be a roundworm parasite. The scientific name of this parasite is Parastrongyloides trichosuri. It is a little worm that lives in the small intestine of the possum. It is found naturally in possums in the North Island of New Zealand and does not seem to harm the possums.
The aim is to genetically modify the nematode worm to produce the hormone-toxin.
If the modified worm that is producing the hormone-toxin infects a possum, it would make possum sterile or at least make it much less fertile than it would normally otherwise be. In other words, the possum would continue to live a normal life, but without having as many babies.
People involved in the project have had to investigate several things:
- Possum reproduction and how the toxin works
- Assessing the suitability of the nematode worm as a vector (carrier) of the toxin
- Modifying the nematode worm so that it can produce the toxin and spread it amongst possums
The role of collaboration is important. Different people are able to contribute in different ways to the project.
- 18 December 2008